Type I (immediate-type) hypersensitivity Natural Rubber Latex Allergy (NRL) is an IgE-mediated, immediate type hypersensitivity reaction to one or more proteins in natural rubber latex (Hevea brasiliensis). Histamine is release causing symptoms. This reaction is systemic.

Type IV (delayed-type) hypersensitivity is a T cell-mediated, delayed response, and typically occurs 48 to 96 hours after exposure. This is frequently a reaction to the processing chemicals used in manufacturing natural rubber latex (NRL). This reaction is generally localized to the area of contact. This reaction is also referred to as allergic contact dermatitis, T-cell-mediated allergy, or chemical allergy.

Irritant Contact Dermatitis is a non-allergic reaction. Symptoms typically are dry, irritated, and/or fissured lesions.

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